Coupling Reactions

Coupling reactions

Amide

Peptide Bond formation

Solid Phase

Solution

DCC
EDC
CDI
Solution-Phase Amide Coupling with DSC
Active Esters

Other Reagents to Consider

  • Acid fluoride (TFFH, cyanuric fluoride)
  • Acid chloride (BTC, trichloroacetonitrile, thionyl chloride)
  • T3P
  • EEDQ and IIDQ
  • Triazines
  • PyBrOP

Ester

Solid Phase

Esterification

Solution Phase

Peptoid

Solid Phase

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